preparation of nitropyridines by nitration of pyridines with nitric acid

If you do not receive an email within 10 minutes, your email address may not be registered, Methods for Preparing Energetic Nitrocompounds: Nitration with Superacid Systems, Nitronium Salts, and Related Complexes. The Reaction of Aromatic Amines with Nitronium Hexafluorophosphate in Nitromethane. Screening procedure for determination of total n-nitroso content in urine.

formally request permission using Copyright Clearance Center. The drawback to this process is that it gives a DADNP yield of not more than 50% of theory.
Organic & Biomolecular Chemistry 2005, 3 (3) , 538. Journal of Molecular Catalysis A: Chemical 2001, 174 (1-2) , 265-277. Preparation of Nitropyridines by Nitration of Pyridines with Nitric Acid. 4 (C-4). 3,5-di:nitro-pyridine or the corresp. 91-015456 03! In H. H. Licht et al., Int. The most favorable results are achieved when the fuming sulfuric acid has a concentration of more than 104% (which corresponds to 20%-oleum) and the nitric acid has a concentration of more than 97%. No abstract is available for this article. Conf. I. Nitropyridines 1. Jens Schmidt and Christian B. W. Stark . George A. Olah, G. K. Surya Prakash, Qi Wang, Xing-ya Li, G. K. Surya Prakash, Jinbo Hu. Nitration of pyridines 1a–o with nitric acid in trifluoroacetic anhydride, gave the corresponding 3-nitropyridines 6a–n in yields of 10–83%. Nitration of pyridine to form 3-nitropyridine is a difficult process because the electrophilic NO 2 + species attaches to the nitrogen, making the pyridine ring even less susceptible toward nitration, similar to any other electrophilic substitution reaction on the pyridine ring. Aromatic substitution. You have to login with your ACS ID befor you can login with your Mendeley account. Use the link below to share a full-text version of this article with your friends and colleagues. PREPARATION OF NITROPYRIDINES We first treated the pyridines with N 2O 5dissolved in liquid SO 2at –11 °C and then poured the reaction mixture into water [4].
General knowledge of the field will enable the skilled person to select suitable substituents, e.g., alkyl, especially lower alkyl such as C1-6 alkyl, halo-alkyl, aralkyl, notably deactivated aralkyl such as nitrotoluenyl. Metallation reactions on halopyridines, often used to introduce functionality into the pyridine ring, are included. 94-290874/36 (1994). In a 3-liter reactor equipped with a rapid stirrer, a large bore neck for solids addition, and a dropping funnel, which was protected against atmospheric moisture entry, 1200 ml of 20%-oleum were cooled to 15° C. In small portions, 2.75 moles (300.1 g) of DAP were added (with quick reclosing of the neck after each addition): this took ninety minutes, and the temperature remained below 25° C., mostly below 20° C. After further stirring for fifteen minutes 240 ml of 100%-nitric acid were slowly added over a period of one hundred and thirty minutes at 18-20° C. In all, about 6 kg of ice were used for cooling during the dissolution and nitration steps. ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:SIKKEMA, DOETZE JAKOB;REEL/FRAME:009226/0230, MAGELLAN SYSTEMS INTERNATIONAL LLC, MARYLAND, ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:AKZO NOBEL N.V.;REEL/FRAME:013782/0266, E. I. I. Jiliang Zhou, Liu Leo Liu, Levy L. Cao, Douglas W. Stephan. Reaction of N-nitropyridinium salts with salts of nitro- and polynitroalkanes. The nitration reaction of Example 1 was performed in a 1-liter reactor at 1/3 scale (somewhat shorter times were needed because of the larger specific cooling area) using ice-water cooling. Nitration of pyridines 1a–o with nitric acid in trifluoroacetic anhydride, gave the corresponding 3-nitropyridines 6a–n in yields of 10–83%. 1.

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